Araki S, Shimada Y, Kaji K, Hayashi H
Department of Molecular Biology, School of Science, Nagoya University, Japan.
Biochem Biophys Res Commun. 1990 May 16;168(3):1194-200. doi: 10.1016/0006-291x(90)91155-l.
Survival and proliferation of many types of vascular endothelial cells are influenced by fibroblast growth factor (FGF)1. Removal of FGF from the medium of human umbilical vein endothelial cells (HUVEC) in culture resulted in death of the cells. Here we show that the death caused by deprivation of FGF is active death or apoptosis, and the process of apoptosis can be inhibited by cycloheximide, an inhibitor of protein synthesis. The present study shows apoptosis occurs in endothelial cells in culture. The process of active death of vascular endothelial cells is inhibited by growth factor. This mechanism may be important for the regulation of vascular organization through the degeneration of vessels.
多种类型的血管内皮细胞的存活和增殖受成纤维细胞生长因子（FGF）1影响。从培养的人脐静脉内皮细胞（HUVEC）培养基中去除FGF会导致细胞死亡。在此我们表明，FGF缺乏导致的死亡是主动死亡或凋亡，并且凋亡过程可被蛋白质合成抑制剂环己酰亚胺抑制。本研究表明凋亡发生在培养的内皮细胞中。血管内皮细胞的主动死亡过程受生长因子抑制。这种机制可能对通过血管退化来调节血管组织很重要。
