Gao F M, Jiang H Y, Yu Y N, Li X L, Wang W H
Laboratory of Industrial Hygiene, Ministry of Public Health, Beijing, PRC.
Sci China B. 1990 Mar;33(3):311-20.
Inj. Hydroxyprogesterone Co. (EP) was injected i.m. into female Wistar rats, different strains of mice of both sex and Syrian golden hamsters with doses of 5-100 times the human contraceptive dose once or twice a month for 10-32 times. In some experiments EP was combined with whole-body 3 Gy gamma ray radiation once or twice. Results show that EP has obvious carcinogenicity and can enhance the gamma ray carcinogenicity, thereby increasing the tumor incidence or the ratio of malignant to benign tumours. Carcinogenic mechanisms of EP have also been studied.
羟孕酮酯（欧洲药典标准）注射液通过肌肉注射给予雌性Wistar大鼠、不同品系的雌雄小鼠以及叙利亚金黄地鼠，剂量为人用避孕剂量的5至100倍，每月注射一次或两次，共注射10至32次。在一些实验中，羟孕酮酯与全身3 Gy的γ射线辐射联合使用一次或两次。结果表明，羟孕酮酯具有明显的致癌性，并且可以增强γ射线致癌性，从而增加肿瘤发生率或恶性肿瘤与良性肿瘤的比例。还对羟孕酮酯的致癌机制进行了研究。
