Semenov V V, Khanin M A
Biofizika. 1990 Jan-Feb;35(1):139-41.
A linear mathematical model of the kinetics of humoral system of hemocoagulation is presented in the works by Levin (1966), Moro a. Brakhucha-Reyd (1969), Martoran a. Moro (1974). Present paper considers a nonlinear mathematical model of the intrinsic path of hemocoagulation which takes into account the effect of positive feed back which is related to the action of factors Va and VIIIa as co-factors. It is found that the intrinsic path of hemocoagulation normally functions as an amplifier cascade, if the wall damage is above some threshold value. When the damage is below the threshold value the intrinsic path of hemocoagulation does not function.
莱文（1966年）、莫罗与布拉胡查 - 雷德（1969年）、马尔托兰与莫罗（1974年）的著作中提出了血液凝固体液系统动力学的线性数学模型。本文考虑了内源性凝血途径的非线性数学模型，该模型考虑了与因子Va和VIIIa作为辅因子的作用相关的正反馈效应。研究发现，如果血管壁损伤高于某个阈值，内源性凝血途径通常作为一个放大级联发挥作用。当损伤低于阈值时，内源性凝血途径不起作用。
