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1
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Appl Microbiol. 1975 Mar;29(3):317-22. doi: 10.1128/am.29.3.317-322.1975.
2
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本文引用的文献

1
Ochratoxin A, a toxic metabolite produced by Aspergillus ochraceus Wilh.赭曲霉毒素A，一种由威尔赭曲霉产生的有毒代谢产物。
Nature. 1965 Mar 13;205(976):1112-3. doi: 10.1038/2051112a0.
2
Changes in fungi with age. 3. Incorporation of amino acids into cells of Rhizoctonia solani and Sclerotium bataticola.真菌随年龄的变化。3. 氨基酸掺入茄丝核菌和甘薯小核菌细胞的情况。
Arch Mikrobiol. 1968;61(4):394-8.
3
Conditions for production of ochratoxin A by Aspergillus species in a synthetic medium.曲霉属在合成培养基中产生赭曲霉毒素A的条件。
Appl Microbiol. 1970 Mar;19(3):542-4. doi: 10.1128/am.19.3.542-544.1970.
4
Biosynthesis of ochratoxin A.赭曲霉毒素A的生物合成
Appl Microbiol. 1969 Oct;18(4):622-7. doi: 10.1128/am.18.4.622-627.1969.
5
The effect of amino acids on the production of ochratoxin A in chemically defined media.氨基酸对化学限定培养基中赭曲霉毒素A产生的影响。
Antonie Van Leeuwenhoek. 1968;34(4):433-40. doi: 10.1007/BF02046465.
6
Bioproduction of ochratoxin A and penicillic acid by members of the Aspergillus ochraceus group.赭曲霉群成员生物合成赭曲霉毒素A和青霉酸。
Can J Microbiol. 1972 May;18(5):631-6. doi: 10.1139/m72-100.
7
Production of penicillic acid and ochratoxin A on poultry feed by Aspergillus ochraceus: temperature and moisture requirements.产黄青霉在禽饲料上产生青霉酸和赭曲霉毒素A：温度和湿度要求
Appl Microbiol. 1973 Aug;26(2):155-60. doi: 10.1128/am.26.2.155-160.1973.
8
Effects of the self-inhibitor of Dictyostelium discoideum on spore metabolism.盘基网柄菌自抑制因子对孢子代谢的影响。
J Gen Microbiol. 1973 Jun;76(2):331-44. doi: 10.1099/00221287-76-2-331.
9
Effect of zinc, copper, and iron on ochratoxin A production.锌、铜和铁对赭曲霉毒素A产生的影响。
Appl Microbiol. 1973 May;25(5):847-9. doi: 10.1128/am.25.5.847-849.1973.
10
Some characteristics of tryptophan uptake in Claviceps species.麦角菌属物种中色氨酸摄取的一些特征。
J Bacteriol. 1973 Apr;114(1):208-19. doi: 10.1128/jb.114.1.208-219.1973.

在赭曲霉毒素A生物合成过程中，赭曲霉中谷氨酸的代谢。

Metabolism of glutamic acid in Aspergillus ochraceus during the biosynthesis of ochratoxin A.

作者信息

Bacon C W, Robbins J D, Burdick D

出版信息

Appl Microbiol. 1975 Mar;29(3):317-22. doi: 10.1128/am.29.3.317-322.1975.

DOI:10.1128/am.29.3.317-322.1975
PMID:234718
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC186973/
Abstract

The uptake and utilization of glutamic acid in the biosynthesis of ochratoxin A by Aspergillus ochraceus were studied. Uniformly labeled L[14C]glutamic acid was incorporated into both the phenylalanine and isocoumarin moieties of ochratoxin A. Penicillic acid was also labeled. During the early stages of development, the amino acid was used mainly for the synthesis of ribonucleic acid and protein. A portion of glutamic acid was oxidized and was recovered as metabolic 14CO-2. The initial uptake velocity of glutamic acid decreased with age and was pH and temperature dependent. No relationship was found between the initial uptake velocities and ochratoxin A biosynthesis.

摘要

研究了赭曲霉在赭曲霉毒素A生物合成中对谷氨酸的摄取和利用。均匀标记的L-[¹⁴C]谷氨酸被掺入到赭曲霉毒素A的苯丙氨酸和异香豆素部分。青霉酸也被标记。在发育早期，氨基酸主要用于核糖核酸和蛋白质的合成。一部分谷氨酸被氧化，并以代谢¹⁴CO₂的形式回收。谷氨酸的初始摄取速度随年龄下降，并且依赖于pH和温度。未发现初始摄取速度与赭曲霉毒素A生物合成之间的关系。