Rice 360°: Institute for Global Health Technologies, Rice University, 6100 Main St., Houston, TX 77005, USA.
Ann Biomed Eng. 2013 Sep;41(9):1860-8. doi: 10.1007/s10439-013-0780-z. Epub 2013 Mar 8.
Pediatricians in Africa requested a tool to improve caregiver dosing of liquid antiretroviral medication. We developed, evaluated and disseminated a clip to control the amount of medication drawn into an oral syringe. In a laboratory, a user tested clips of different lengths, corresponding to different volumes, by drawing water into a syringe with a clip. In Texas and Malawi, 149 adults attempted to measure Pepto-Bismol™ using a syringe with a clip, a syringe without a clip, and a dosing cup, in a randomly assigned order. In the laboratory, the volume of liquid, ranging from 1 to 4.5 mL, drawn into the syringe was always within at least 5 μL of the intended dose. In Texas, 84% of doses were accurate within ±10%, vs. 63% using the syringe alone, and 21% with the dosing cup. In Malawi, 98% of doses were accurate to within ±10%, vs. 90% using the syringe alone, and 27% with the dosing cup. For target accuracy values within ±45% (±21%), a significantly higher fraction of Houston (Kamangira) participants delivered an accurate dose using the syringe with the clip than with the syringe alone (p < 0.05). The clip enables a greater proportion of users to accurately measure liquid medication.
非洲的儿科医生需要一种工具来帮助照顾者准确给儿童喂服液体制剂的抗逆转录病毒药物。我们研发、评估并推广了一种可以控制口服注射器注药量的夹子。在实验室中，用户通过将夹子夹在注射器上来测试不同长度的夹子，这些夹子对应不同的容量，然后向注射器中吸入水。在德克萨斯州和马拉维，149 名成年人按照随机顺序，使用带夹的注射器、不带夹的注射器和量杯尝试测量 Pepto-BismolTM 的剂量。在实验室中，从 1 到 4.5 毫升的液体量总是被准确吸入注射器，误差不超过 5 微升。在德克萨斯州，84%的剂量误差在±10%以内，而单独使用注射器的误差为 63%，使用量杯的误差为 21%。在马拉维，98%的剂量误差在±10%以内，而单独使用注射器的误差为 90%，使用量杯的误差为 27%。对于目标精度值在±45%（±21%）以内的情况，使用带夹的注射器的休斯顿（卡芒加拉）参与者中，有更高比例的人能够准确地输送药物剂量，这一比例显著高于单独使用注射器的情况（p<0.05）。夹子使更多的用户能够更准确地测量液体药物。
