Samuels Eric R, McNary Joshua, Aguilar Maribel, Awad Ahmed M
Chemistry Program, California State University Channel Islands, Camarillo, CA 93012, USA.
Nucleosides Nucleotides Nucleic Acids. 2013;32(3):109-23. doi: 10.1080/15257770.2013.766752.
Two synthetic routes to 3'-deoxy-3'-azido nucleosides are described, one toward the synthesis of 3'-deoxy-3'-azidouridine and a second toward 3'-deoxy-3'-azidocytidine. The target compounds may serve as precursors to provide building blocks for use in automated synthesis of guanidine-linked RNA analogs (RNG) or oligonucleotide N3'→P5' phosphoramidates. Moreover, the synthetic approaches are adaptable to the general synthesis of 3'-substituted 3'-deoxynucleosides for development of new antiviral drugs.
描述了两种合成3'-脱氧-3'-叠氮基核苷的路线，一种用于合成3'-脱氧-3'-叠氮基尿苷，另一种用于合成3'-脱氧-3'-叠氮基胞苷。目标化合物可用作前体，为用于胍连接的RNA类似物（RNG）或寡核苷酸N3'→P5'亚磷酰胺的自动化合成提供构建模块。此外，这些合成方法适用于3'-取代的3'-脱氧核苷的一般合成，以开发新的抗病毒药物。
