MicroRNAs 作为竞争 RNA 之间选择性通讯通道：稳态理论。
MicroRNAs as a selective channel of communication between competing RNAs: a steady-state theory.
机构信息
Dipartimento di Fisica, Sapienza Universitá di Roma, Roma, Italy.
出版信息
Biophys J. 2013 Mar 5;104(5):1203-13. doi: 10.1016/j.bpj.2013.01.012.
It has recently been suggested that the competition for a finite pool of microRNAs (miRNA) gives rise to effective interactions among their common targets (competing endogenous RNAs or ceRNAs) that could prove to be crucial for posttranscriptional regulation. We have studied a minimal model of posttranscriptional regulation where the emergence and the nature of such interactions can be characterized in detail at steady state. Sensitivity analysis shows that binding free energies and repression mechanisms are the key ingredients for the cross-talk between ceRNAs to arise. Interactions emerge in specific ranges of repression values, can be symmetrical (one ceRNA influences another and vice versa) or asymmetrical (one ceRNA influences another but not the reverse), and may be highly selective, while possibly limited by noise. In addition, we show that nontrivial correlations among ceRNAs can emerge in experimental readouts due to transcriptional fluctuations even in the absence of miRNA-mediated cross-talk.
最近有人提出，有限 miRNA（miRNA）池的竞争导致其共同靶标（竞争内源性 RNA 或 ceRNA）之间产生有效的相互作用，这可能对转录后调控至关重要。我们研究了一个最小的转录后调控模型，其中可以在稳态下详细描述这些相互作用的出现和性质。敏感性分析表明，结合自由能和抑制机制是 ceRNA 之间交叉对话出现的关键因素。相互作用出现在特定的抑制值范围内，可以是对称的（一个 ceRNA 影响另一个 ceRNA，反之亦然）或不对称的（一个 ceRNA 影响另一个 ceRNA，但反之不然），并且可能具有高度选择性，同时可能受到噪声的限制。此外，我们还表明，即使不存在 miRNA 介导的交叉对话，由于转录波动，ceRNA 之间也可能在实验读数中出现非平凡相关性。
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