一种 ceRNA 假说：隐藏 RNA 语言的罗塞塔石碑？
A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language?
机构信息
Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
出版信息
Cell. 2011 Aug 5;146(3):353-8. doi: 10.1016/j.cell.2011.07.014. Epub 2011 Jul 28.
Abstract
Here, we present a unifying hypothesis about how messenger RNAs, transcribed pseudogenes, and long noncoding RNAs "talk" to each other using microRNA response elements (MREs) as letters of a new language. We propose that this "competing endogenous RNA" (ceRNA) activity forms a large-scale regulatory network across the transcriptome, greatly expanding the functional genetic information in the human genome and playing important roles in pathological conditions, such as cancer.
摘要
在这里，我们提出了一个统一的假说，即信使 RNA、转录假基因和长非编码 RNA 如何使用 microRNA 反应元件 (MRE) 作为一种新语言的字母相互“交流”。我们提出，这种“竞争内源性 RNA”（ceRNA）活性在整个转录组中形成了一个大规模的调控网络，极大地扩展了人类基因组中的功能遗传信息，并在癌症等病理条件下发挥重要作用。
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