既往静脉吸毒致滑石肺肉芽肿患者肺移植的长期预后

Long-term outcome of lung transplantation in previous intravenous drug users with talc lung granulomatosis.

作者信息

Weinkauf J G, Puttagunta L, Nador R, Jackson K, LaBranche K, Kapasi A, Mullen J, Modry D L, Stewart K C, Thakrar M, Doucette K, Lien D C

机构信息

Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.

出版信息

Transplant Proc. 2013 Jul-Aug;45(6):2375-7. doi: 10.1016/j.transproceed.2012.11.004. Epub 2013 Mar 7.

DOI:10.1016/j.transproceed.2012.11.004

PMID:23473657

Abstract

Talc lung granulomatosis results from the intravenous use of medication intended for oral use. Talc (magnesium silicate) acts as filler in some oral medications; when injected intravenously, it deposits in the lungs leading to airflow obstruction and impaired gas exchange. Allocation of donor lungs to previous intravenous drug users is controversial. After a careful selection process, 19 patients with talc lung granulomatosis have received lung allografts in our program. Long-term survival for these patients is excellent and our results suggest the previous use of intravenous drugs should not necessarily preclude lung transplantation.

摘要

滑石粉肺肉芽肿病是由静脉注射口服药物引起的。滑石粉（硅酸镁）在一些口服药物中用作填充剂；静脉注射时，它会沉积在肺部，导致气流阻塞和气体交换受损。将供体肺分配给以前的静脉吸毒者存在争议。经过仔细的筛选过程，19例滑石粉肺肉芽肿病患者在我们的项目中接受了肺移植。这些患者的长期存活率很高，我们的结果表明，以前使用静脉药物不一定会排除肺移植。