疫苗设计：新兴概念与重燃的乐观主义。
Vaccine design: emerging concepts and renewed optimism.
机构信息
Thayer School of Engineering, Dartmouth College, NH, USA.
出版信息
Curr Opin Biotechnol. 2013 Dec;24(6):1078-88. doi: 10.1016/j.copbio.2013.02.015. Epub 2013 Mar 7.
Abstract
Arguably, vaccination represents the single most effective medical intervention ever developed. Yet, vaccines have failed to provide any or adequate protection against some of the most significant global diseases. The pathogens responsible for these vaccine-recalcitrant diseases have properties that allow them to evade immune surveillance and misdirect or eliminate the immune response. However, genomic and systems biology tools, novel adjuvants and delivery systems, and refined molecular insight into protective immunity have started to redefine the landscape, and results from recent efficacy trials of HIV and malaria vaccines have instilled hope that another golden age of vaccines may be on the horizon.
摘要
可以说，疫苗接种是有史以来最有效的医学干预手段之一。然而，疫苗未能为一些最严重的全球疾病提供任何或充分的保护。导致这些疫苗难治性疾病的病原体具有使其逃避免疫监测、误导或消除免疫反应的特性。然而，基因组和系统生物学工具、新型佐剂和递送系统，以及对保护性免疫的深入分子认识，开始重新定义这一领域，最近艾滋病毒和疟疾疫苗的疗效试验结果带来了希望，另一个疫苗的黄金时代可能即将到来。
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