Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, K.U.Leuven, 3000, Leuven, Belgium.
Cell Mol Life Sci. 2013 May;70(10):1763-78. doi: 10.1007/s00018-013-1283-7. Epub 2013 Mar 12.
Intensive research in the last decade shows that the prototypic angiogenic factor vascular endothelial growth factor (VEGF) can have direct effects in neurons and modulate processes such as neuronal migration, axon outgrowth, axon guidance and neuronal survival. Depending on the neuronal cell type and the process, VEGF seems to exert these effects by signaling via different receptors. It is also becoming clear that other VEGF ligands such as VEGF-B, -C and -D can act in various neuronal cell types as well. Moreover, apart from playing a role in physiological conditions, VEGF and VEGF-B have been related to different neurological disorders. We give an update on how VEGF controls different processes during neurodevelopment as well as on its role in several neurodegenerative disorders. We also discuss recent findings demonstrating that other VEGF ligands influence processes such as neurogenesis and dendrite arborization and participate in neurodegeneration.
在过去十年中进行的深入研究表明，典型的血管生成因子血管内皮生长因子 (VEGF) 可以直接作用于神经元，并调节神经元迁移、轴突生长、轴突导向和神经元存活等过程。根据神经元细胞类型和过程的不同，VEGF 似乎通过不同的受体信号传递来发挥这些作用。此外，其他 VEGF 配体，如 VEGF-B、-C 和 -D，也可以在各种神经元细胞类型中发挥作用。此外，除了在生理条件下发挥作用外，VEGF 和 VEGF-B 还与不同的神经紊乱有关。我们将更新 VEGF 如何控制神经发育过程中的不同过程，以及它在几种神经退行性疾病中的作用。我们还讨论了最近的发现，这些发现表明其他 VEGF 配体影响神经发生和树突分支等过程，并参与神经退行性变。
