Chong B H, Kaplin I J
Department of Haematology, St. George Hospital, Kogarah, Australia.
Haemostasis. 1990;20(2):106-11. doi: 10.1159/000216115.
The effects of quinidine on platelets over a wide range of concentrations of the drug were studied. It was found that quinidine at high concentrations (1 and 1.5 mM) induced platelets to undergo profound ultrastructural changes and 14C-serotonin release. In addition, the drug at these concentrations caused marked inhibition of platelet aggregation mediated by adenosine diphosphate, adrenaline, collagen and arachidonate but had no effect on ristocetin-induced agglutination. However, quinidine at 10 microM (a pharmacological concentration) had only a variable inhibitory effect on adrenaline-induced platelet aggregation.
研究了奎尼丁在广泛药物浓度范围内对血小板的影响。发现高浓度（1和1.5 mM）的奎尼丁可诱导血小板发生深刻的超微结构变化并释放14C-血清素。此外，这些浓度的药物可显著抑制由二磷酸腺苷、肾上腺素、胶原蛋白和花生四烯酸介导的血小板聚集，但对瑞斯托菌素诱导的凝集没有影响。然而，10 microM（药理浓度）的奎尼丁对肾上腺素诱导的血小板聚集仅有可变的抑制作用。
