[Evaluation of transdermal property in vitro of different breviscapine lipid carrier gels].

OBJECTIVE

To prepare four breviscapine lipid carrier gels and general gel, and to study the transdermal promotive effects of them in vitro.

METHOD

Improved Franz-type diffusion cell and isolated rat skin were used as transdermal barrier, and the transdermal property was fitted by pharmacokinetics equations. The unit area cumulative permeation quantity of breviscapine was determined by HPLC method.

RESULT

The 24 hours' unit area cumulative permeation quantity of SLN gel was the highest, followed in descending order were transfersomal gel, liposomal gel, NLC gel and general gel. The transdermal property in vitro of SLN gel fitted in with Higuchi pharmacokinetics equation.

CONCLUSION

The lipid carrier gels had different transdermal promotive effects to breviscapine, SLN gel was the best one as breviscapine transdermal carrier.