Zuo Ai-Hua, Cheng Meng-Chun, Wang Li, Xiao Hong-Bin
Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Science, Dalian 116023, China.
Zhongguo Zhong Yao Za Zhi. 2012 Dec;37(23):3647-50.
To analyze and identify the chemical constituents in rat brain tissues after oral administration of Chuanxiong Rhizoma extracts.
The dosed and blank rat brain tissues were analyzed by UPLC-Q-TOF-MS. Different peaks were observed in total ion chromatograms and then identified according to their retention time, accurate mass weight, MS and MS/MS data.
After oral administration of Chuanxiong Rhizoma extracts, 3 compounds were absorbed into rat brain tissues through BBB. They were identified as senkyunolide I, senkyunolide A and ligustilide.
The study is helpful for interpreting effective substance of Ligusticum chuanxiong.
分析并鉴定口服川芎提取物后大鼠脑组织中的化学成分。
采用超高效液相色谱-四极杆飞行时间质谱联用仪（UPLC-Q-TOF-MS）对给药大鼠和空白大鼠的脑组织进行分析。在总离子色谱图中观察到不同的峰，然后根据它们的保留时间、精确分子量、质谱和串联质谱数据进行鉴定。
口服川芎提取物后，3种化合物通过血脑屏障被吸收进入大鼠脑组织。它们被鉴定为藁本内酯I、藁本内酯A和川芎嗪。
该研究有助于阐释川芎的有效成分。
