Gorodetsky R, Mou X D, Fisher D R, Taylor J M, Withers H R
Sharrett Institute of Oncology, Haddassah University Hospital, Jerusalem, Israel.
Int J Radiat Oncol Biol Phys. 1990 May;18(5):1077-81. doi: 10.1016/0360-3016(90)90443-n.
Radiation induced dermal injury was measured by the gain in the physical strength of healing wounds in mouse skin. A sigmoid dose response for the inhibition of wound healing 14 days after surgery was found for single doses of X rays. The sparing of dermal damage from fractionation of the X-ray dose was quantified in terms of the alpha/beta ratio in the linear-quadratic (LQ) model, at a wide range of doses per fraction reaching as low as about 1 Gy. The fit and the appropriateness of the LQ model for the skin wound healing assay was examined with the use of the Fe-plot in which inverse total dose is plotted versus dose per fraction for wound strength isoeffects. The alpha/beta ratio of the skin was about 2.5 Gy (95% confidence of less than +/- 1 Gy) and was appropriate over a dose range of 1 Gy to about 8 Gy. The low alpha/beta value is typical for a late responding tissue. This assay, therefore, has the advantage of measuring and forecasting late radiation responses of the dermis within a short time after irradiation.
通过测量小鼠皮肤愈合伤口的物理强度增加来评估辐射诱导的皮肤损伤。对于单次X射线照射，发现术后14天伤口愈合抑制呈S形剂量反应。在广泛的分次剂量范围内，低至约1 Gy，根据线性二次（LQ）模型中的α/β比值对X射线剂量分次照射时皮肤损伤的减轻进行了量化。使用Fe图检查了LQ模型对皮肤伤口愈合试验的拟合度和适用性，在Fe图中，绘制了伤口强度等效应的总剂量倒数与分次剂量的关系。皮肤的α/β比值约为2.5 Gy（95%置信区间小于±1 Gy），在1 Gy至约8 Gy的剂量范围内适用。低α/β值是晚期反应组织的典型特征。因此，该试验具有在照射后短时间内测量和预测真皮晚期辐射反应的优势。
