Psychiatric Hospital Idrija, Pot sv. Antona 49, 5280 Idrija, Slovenia.
Psychiatry Res. 2013 Nov 30;210(1):89-94. doi: 10.1016/j.psychres.2013.01.032. Epub 2013 Mar 9.
The aim of study was to assess cognition in patients with late onset depression in a symptom-free remission period measuring event-related potentials and reaction times (RT) in a modified computer version of the Stroop test. Thirty four patients with late-onset depression were included after they had reached remission. They were compared to age-, gender- and education-matched healthy controls. Each participant completed a single item computer version of the Stroop Color-word task using verbal response mode. EEG and RT were simultaneously recorded. RTs were significantly prolonged in patients in all conditions of the Stroop paradigm, and the interference effect was significantly greater in patients compared to controls. Results also revealed abnormal late positive Stroop related potentials in the period of about 500-600 ms period corresponding to the so-called P300b wave. Our study supports the view that patients with late onset depression are also cognitively impaired and that this impairment persists in the period of early remission. Using more sensitive ERP measurement of the Stroop task we demonstrated impaired information processing at an earlier, pre-response related stage.
本研究旨在评估处于无症状缓解期的晚发性抑郁症患者的认知功能，采用改良后的 Stroop 测试计算机版本来测量事件相关电位和反应时 (RT)。34 例晚发性抑郁症患者在达到缓解后被纳入研究。他们与年龄、性别和教育程度匹配的健康对照组进行了比较。每位参与者都使用言语反应模式完成了 Stroop 颜色词任务的单一项目计算机版本。同时记录 EEG 和 RT。在 Stroop 范式的所有条件下，患者的 RT 明显延长，与对照组相比，患者的干扰效应明显更大。结果还显示，在大约 500-600ms 期间，与所谓的 P300b 波相对应的晚正相关 Stroop 相关电位异常。我们的研究支持这样一种观点，即晚发性抑郁症患者的认知也受损，而且这种损害在早期缓解期仍然存在。通过对 Stroop 任务进行更敏感的 ERP 测量，我们证明了在更早的、与反应无关的阶段，信息处理受损。
