Lenane M C, Swedo S E, Leonard H, Pauls D L, Sceery W, Rapoport J L
Child Psychiatry Branch, NIMH, Bethesda, MD 20892.
J Am Acad Child Adolesc Psychiatry. 1990 May;29(3):407-12. doi: 10.1097/00004583-199005000-00012.
One hundred and forty-five first-degree relatives (89 parents [96%] and 56 siblings [98%]) of 46 children and adolescents with severe primary obsessive compulsive disorder (OCD) were personally interviewed with clinical and structured psychiatric interviews. Parent interviews were scored by a rater blind to proband diagnosis. Thirty percent of probands had at least one first-degree relative with OCD: 25% of fathers and 9% of mothers received this diagnosis. Forty-five percent of fathers and 65% of mothers received one or more other psychiatric diagnoses. The increased familial rate of OCD over that expected from a general population, and over that found in parents of conduct disordered patients, is consistent with a genetic factor in OCD. Presenting obsessive compulsive symptoms of probands and their parents were usually dissimilar, arguing against any simple social or cultural transmission.
对46名患有严重原发性强迫症（OCD）的儿童和青少年的145名一级亲属（89名父母[96%]和56名兄弟姐妹[98%]）进行了临床和结构化精神科访谈。父母访谈由一名对先证者诊断不知情的评估者评分。30%的先证者至少有一名患有强迫症的一级亲属：25%的父亲和9%的母亲被诊断为此病。45%的父亲和65%的母亲接受了一种或多种其他精神科诊断。强迫症的家族发病率高于一般人群预期，也高于品行障碍患者父母中的发病率，这与强迫症中的遗传因素一致。先证者及其父母出现的强迫症状通常不同，这排除了任何简单的社会或文化传播因素。
