Yang Y, Liu X
Institute of Mental Health, West China University of Medical Sciences, Chengdu, Sichuan, 610041 P. R. China.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 1998 Oct 10;15(5):303-6.
To explore the genetic etiology of obsessive-compulsive disorder (OCD) and genetic association between OCD and tic disorder.
The mental disorders in the first degree and second degree relatives of 90 probands with OCD were investigated and compared with those of 100 healthy families by the method of family genetic study.
Compared to the control, the prevalence rates of schizophrenia, affective disorder, minor depression, subclinical OCD, general anxiety disorder and tic disorder in the first degree relatives of OCD were elevated, except that of OCD. The prevalence rates of OCD and subclinical OCD, general anxiety disorder, and other neurotic disorders in the first degree relatives of patients with pure obsession were 47.6%, 35.7% and 23.8%, respectively; compared to 10.8%, 3.6% and 0 in those of the control (P<0.01). The prevalence rates of schizophrenia,affective disorder,and tic disorder in the first degree relatives of OCD with tic were 52.0%, 26.0% and 90.9%, respectively; compared to 0, 3.6% and 7.2% in those of the control (P<0.01).
The etiology of OCD is related to heredity. There was evidence to show genetic association between OCD and tic disorder,The elevation of prevalence rates of various mental disorders in the first degree relatives of OCD might suggest the genetic basis of various subtypes of OCD.
探讨强迫症（OCD）的遗传病因以及OCD与抽动障碍之间的遗传关联。
采用家系遗传学研究方法，对90例OCD先证者的一级和二级亲属中的精神障碍进行调查，并与100个健康家庭的亲属进行比较。
与对照组相比，OCD一级亲属中精神分裂症、情感障碍、轻度抑郁、亚临床OCD、广泛性焦虑障碍和抽动障碍的患病率均升高，但OCD本身患病率除外。单纯强迫观念患者一级亲属中OCD、亚临床OCD、广泛性焦虑障碍及其他神经症性障碍的患病率分别为47.6%、35.7%和23.8%；而对照组分别为10.8%、3.6%和0（P<0.01）。伴有抽动的OCD患者一级亲属中精神分裂症、情感障碍和抽动障碍的患病率分别为52.0%、26.0%和90.9%；而对照组分别为0、3.6%和7.2%（P<0.01）。
OCD的病因与遗传有关。有证据表明OCD与抽动障碍之间存在遗传关联，OCD一级亲属中各种精神障碍患病率的升高可能提示OCD各亚型的遗传基础。
