Jáuregui-Garrido B, Jáuregui-Lobera I
Department of Cardiology, Universitary Hospital Virgen del Rocío, Seville, Spain.
Nutr Hosp. 2012 Sep-Oct;27(5):1399-407. doi: 10.3305/nh.2012.27.5.5925.
A drug interaction is defined as any alteration, pharmacokinetics and/or pharmacodynamics, produced by different substances, other drug treatments, dietary factors and habits such as drinking and smoking. These interactions can affect the antiarrhythmic drugs, altering their therapeutic efficacy and adverse effects. The aim of this study was to conduct a review of available data about interactions between antiarrhythmic drugs and food.
The purpose of this review was to report an update of the existing literature data on the main findings with respect to food and antiarrhythmic drugs interactions by means of a search conducted in PubMed, which yielded a total of 250 articles initially.
After excluding different articles which were not focusing on the specific objective, the main results refer to interactions among antiarrhythmic drugs and food in general, grapefruit juice, and others like fibre or medicinal plants.
Food may affect the bioavailability of antiarrhythmic drugs and in some specific cases (dairy products, rich-in-protein diets, grapefruit juice), this should be carefully considered. The best recommendation seems to advise patients to remove the grapefruit juice from their diet when treatment with these drugs. Fibre should be separated from taking these drugs and regarding medicinal plants and given their increased use, the anamnesis must include information about its use, the reason for that use and what types of plants are used, all in order to give the corresponding recommendations.
药物相互作用被定义为不同物质、其他药物治疗、饮食因素以及饮酒和吸烟等习惯所产生的任何药代动力学和/或药效学改变。这些相互作用可能会影响抗心律失常药物，改变其治疗效果和不良反应。本研究的目的是对有关抗心律失常药物与食物相互作用的现有数据进行综述。
本综述的目的是通过在PubMed上进行检索，报告关于食物与抗心律失常药物相互作用的现有文献数据的更新情况，最初共检索到250篇文章。
在排除了不关注特定目标的不同文章后，主要结果涉及抗心律失常药物与一般食物、葡萄柚汁以及其他如纤维或药用植物之间的相互作用。
食物可能会影响抗心律失常药物的生物利用度，在某些特定情况下（乳制品、高蛋白饮食、葡萄柚汁），这一点应予以仔细考虑。最佳建议似乎是建议患者在使用这些药物进行治疗时，从饮食中去除葡萄柚汁。服用这些药物时应与纤维分开，鉴于药用植物的使用增加，问诊必须包括其使用信息、使用原因以及所使用的植物类型，所有这些都是为了给出相应的建议。
