Brown K A, Slinker B K
Cardiology Unit, University of Vermont College of Medicine, Burlington.
J Nucl Med. 1990 Jun;31(6):1020-4.
Dipyridamole-thallium-201 imaging is often performed in patients unable to exercise because of peripheral vascular disease. Many of these patients are taking pentoxifylline (Trental), a methylxanthine derivative which may improve intermittent claudication. Whether pentoxifylline inhibits dipyridamole-induced coronary hyperemia like other methylxanthines such as theophylline and should be stopped prior to dipyridamole-thallium-201 imaging is unknown. Therefore, we studied the hyperemic response to dipyridamole in seven open-chest anesthetized dogs after pretreatment with either pentoxifylline (0, 7.5, or 15 mg/kg i.v.) or theophylline (3 mg/kg i.v.). Baseline circumflex coronary blood flows did not differ significantly among treatment groups. Dipyridamole significantly increased coronary blood flow before and after 7.5 or 15 mm/kg i.v. pentoxifylline (p less than 0.002). Neither dose of pentoxifylline significantly decreased the dipyridamole-induced hyperemia, while peak coronary blood flow was significantly lower after theophylline (p less than 0.01). We conclude that pentoxyifylline does not inhibit dipyridamole-induced coronary hyperemia even at high doses.
双嘧达莫 - 铊 - 201成像常用于因外周血管疾病而无法运动的患者。这些患者中有许多正在服用己酮可可碱（曲克芦丁），一种甲基黄嘌呤衍生物，可能会改善间歇性跛行。己酮可可碱是否像其他甲基黄嘌呤如茶碱一样抑制双嘧达莫诱导的冠状动脉充血，以及在双嘧达莫 - 铊 - 201成像前是否应停药尚不清楚。因此，我们在用己酮可可碱（0、7.5或15mg/kg静脉注射）或茶碱（3mg/kg静脉注射）预处理后，研究了七只开胸麻醉犬对双嘧达莫的充血反应。各治疗组之间的基线左旋冠状动脉血流量无显著差异。静脉注射7.5或15mg/kg己酮可可碱前后，双嘧达莫均显著增加冠状动脉血流量（p<0.002）。两种剂量的己酮可可碱均未显著降低双嘧达莫诱导的充血，而茶碱后冠状动脉血流量峰值显著降低（p<0.01）。我们得出结论，即使在高剂量下，己酮可可碱也不会抑制双嘧达莫诱导的冠状动脉充血。
