Department of Oncogene Regulation, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Kolkata 700026, India.
Anticancer Res. 2013 Mar;33(3):1215-20.
This study examined the prognostic significance of candidate tumor suppressor genes (TSGs) PHD finger protein-2 (PHF2), Fanconi anaemia complementation group C (FANCC) and human homologue of Drosophila patched gene (PTCH1), in head and neck squamous cell carcinoma (HNSCC) treated primarily with surgery, or surgery followed by adjuvant radiotherapy.
Eighty-four patients with HNSCC were followed-up for recurrence/death for up to five years after diagnosis. Molecular alterations (deletion/methylation) of TSGs and human papilloma virus (HPV) status were determined in previous studies of our group. Statistical analyses of correlation of genetic alterations with treatment response and survival were carried out.
Alterations of FANCC and PTCH1 were significantly associated with locoregional recurrence/death. In the surgery with adjuvant radiotherapy-group (n=56), patients showing alterations in FANCC and in PTCH1 were seven- and six-times, respectively, more likely to have locoregional recurrence compared to those with no alterations. In addition, the presence of alterations of both FANCC and PTCH1 had remarkable prognostic significance.
FANCC and PTCH1 alterations might be used as molecular markers for prognosis and to develop strategies for effective treatment planning.
本研究旨在探讨候选抑癌基因（TSGs）PHD 指状蛋白-2（PHF2）、范可尼贫血互补群 C（FANCC）和果蝇 patched 基因（PTCH1）的人类同源物在头颈部鳞状细胞癌（HNSCC）患者中的预后意义，这些患者主要接受手术治疗或手术加辅助放疗。
84 例 HNSCC 患者在诊断后最多随访 5 年以记录复发/死亡情况。本研究组之前的研究中确定了 TSGs 的分子改变（缺失/甲基化）和人乳头瘤病毒（HPV）状态。对遗传改变与治疗反应和生存的相关性进行了统计分析。
FANCC 和 PTCH1 的改变与局部区域复发/死亡显著相关。在接受手术加辅助放疗的 56 例患者中，与无改变的患者相比，FANCC 和 PTCH1 改变的患者局部区域复发的可能性分别增加了 7 倍和 6 倍。此外，FANCC 和 PTCH1 改变的存在具有显著的预后意义。
FANCC 和 PTCH1 的改变可以作为预测分子标志物，以制定有效的治疗计划策略。
