范科尼贫血：鳞状细胞癌的年轻高危患者。
Fanconi anemia: young patients at high risk for squamous cell carcinoma.
作者信息
Velleuer Eunike, Dietrich Ralf
机构信息
Clinic for Pediatric Oncology, Hematology and Clinical Immunology, Children's Hospital, University Hospital of Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Germany.
Deutsche Fanconi-Anämie-Hilfe e.V., Böckenweg 4, 59427, Unna-Siddinghausen, Germany.
出版信息
Mol Cell Pediatr. 2014 Dec;1(1):9. doi: 10.1186/s40348-014-0009-8. Epub 2014 Nov 1.
BACKGROUND
Fanconi anemia is one of the best studied inherited cancer-prone diseases. Greatly improved protocols for hematopoietic stem cell transplantation increasingly save the lives of these young patients. However, in both transplanted and not transplanted patients, the emergence of aggressive squamous cell carcinoma represents a major medical challenge.
CONCLUSIONS
This mini review summarizes current knowledge about the pathogenesis of squamous cell carcinoma (SCC) in the special context of Fanconi anemia.
背景
范可尼贫血是研究最为深入的遗传性易患癌疾病之一。造血干细胞移植方案的大幅改进越来越多地挽救了这些年轻患者的生命。然而，在接受移植和未接受移植的患者中，侵袭性鳞状细胞癌的出现都是一项重大医学挑战。
结论
本综述总结了在范可尼贫血这一特殊背景下鳞状细胞癌（SCC）发病机制的现有知识。
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