Griffiths S P, Gersony W M
Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY 10032.
J Pediatr. 1990 Jun;116(6):882-7. doi: 10.1016/s0022-3476(05)80644-4.
One hundred fifteen attacks of acute rheumatic fever were observed during the past two decades (1969 to 1988) at the Columbia-Presbyterian Medical Center; 104 were initial attacks and 11 were recurrences. The maximum number of cases (18) occurred during the first year of this period, 1969; thereafter the annual incidence decreased until a resurgence was apparent in 1985 to 1986, with 25 cases. There were no differences in the frequency of major manifestations nor the severity of carditis in the 1970s compared with the 1980s. Polyarthritis alone was present in 51 cases, carditis alone in 31, and combined carditis and polyarthritis in 28; chorea was diagnosed in 5. Congestive heart failure occurred in 17 attacks of carditis, including one death from fulminant disease in 1982. In contrast to recent reports, the majority of the affected population was urban, low income, and from crowded communities: more than half were Hispanic, predominantly from Dominican Republic families. The prevalence of acute rheumatic fever underscores the need for early detection and treatment of streptococcal pharyngitis. The observation that 9.5% of the attacks were recurrent reflects failure to comply with antimicrobial prophylaxis and reaffirms the need for more effective secondary prevention programs.
在过去二十年(1969年至1988年)间,哥伦比亚长老会医学中心观察到115例急性风湿热发作;其中104例为首次发作,11例为复发。病例数最多的一年(18例)出现在这一时期的第一年,即1969年;此后年发病率下降,直到1985年至1986年出现回升,有25例。与20世纪80年代相比,20世纪70年代主要表现的频率和心脏炎的严重程度并无差异。仅患多关节炎的有51例,仅患心脏炎的有31例,同时患心脏炎和多关节炎的有28例;确诊患舞蹈病的有5例。17例心脏炎发作出现充血性心力衰竭,其中1982年有1例因暴发性疾病死亡。与最近的报告不同,大多数患病人群来自城市、低收入且居住社区拥挤:超过一半是西班牙裔,主要来自多米尼加共和国家庭。急性风湿热的流行凸显了早期发现和治疗链球菌性咽炎的必要性。9.5%的发作是复发这一观察结果反映出抗菌预防措施未得到遵守,再次强调了需要更有效的二级预防方案。