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肾同种异体移植主动条件受体中的细胞免疫(作者译)

[Cellular immunity in actively conditioned recipients of renal allotransplants (author's transl)].

作者信息

Haefen U V, Garovoy M R, Wren S F, Martins A C, Wilson R E

出版信息

Dtsch Med Wochenschr. 1975 Feb 21;100(8):370-2.

PMID:234839
Abstract

The presence of circulating "killer" cells was demonstrated in actively "conditioned" rats with permanently accepted renal allotransplants. Immunocompetant cells of these animals were able to develop a normal graft-versus-host reaction 100 and 200 days after the transplantation. The ability of these recipients simultaneously to accept secondary donor-specific skin transplants without demonstrable immunological rejection is compatible with the concept that the cytotoxic potential of these cells in vivo is inhibited by enhancing antibodies.

摘要

在具有永久接受的同种异体肾移植的主动“预处理”大鼠中证实了循环“杀伤”细胞的存在。这些动物的免疫活性细胞在移植后100天和200天能够产生正常的移植物抗宿主反应。这些受体同时接受二次供体特异性皮肤移植而无明显免疫排斥的能力与以下概念相符,即这些细胞在体内的细胞毒性潜力受到增强抗体的抑制。

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