Chutná J, Hasek M
Folia Biol (Praha). 1975;21(4):219-27.
The mechanism of prolongation of skin allograft survival in rats treated with specific antigen and hydrocortisone was studied in the strain combination with the strong (H-1 + non-H-1) and weak (non-H-1) antigenic difference. The grafts differing from the recipients at the weak non-H-1 loci only showed the longest survival although unresponsiveness to the strong (H-1) antigens of the donor type had already disappeared. In both strain combinations, immunological reactivity of lymphoid cells from treated animals was demonstrated in local GVH reactions at the end of the treatment (i.e., 12 days after transplantation). Lymphoid cells isolated from long surviving (100 days) AVN recipients of non-H-1 different grafts did not react in the GVH test. Attempts to obtain prolongation of skin allograft survival by passive transfer of serum removed after termination of immunization with strong (H-1 + non-H-1) or only weak (non-H-1) antigens were not successful.
在具有强（H-1 + 非H-1）和弱（非H-1）抗原差异的品系组合中，研究了用特异性抗原和氢化可的松处理的大鼠皮肤同种异体移植存活期延长的机制。仅在弱非H-1位点与受体不同的移植物显示出最长的存活期，尽管对供体类型的强（H-1）抗原的无反应性已经消失。在两种品系组合中，在处理结束时（即移植后12天）的局部GVH反应中证明了来自处理动物的淋巴细胞的免疫反应性。从非H-1不同移植物的长期存活（100天）AVN受体分离的淋巴细胞在GVH试验中没有反应。通过被动转移在用强（H-1 + 非H-1）或仅弱（非H-1）抗原免疫终止后去除的血清来延长皮肤同种异体移植存活期的尝试未成功。
