Klimov L O, Fedoseeva L A, Ryazanova M A, Dymshits G M, Markel A L
Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
Bull Exp Biol Med. 2013 Jan;154(3):357-60. doi: 10.1007/s10517-013-1950-6.
We studied the expression of genes encoding angiotensinogen (Agt), renin (Ren), angiotensin-converting enzyme (ACE), and type 1 angiotensin receptor (AT1A) in the hypothalamus and medulla oblongata of hypertensive ISIAH rats and normotensive WAG rats. The amount of Agt mRNA in the hypothalamus of young ISIAH rats was increased by 30% compared to WAG controls. In the medulla oblongata of young ISIAH rats, the levels of mRNA of Agt and AT1A receptor were enhanced by 60% and 24%, respectively, compared to WAG rats. In adult animals, the expression of the studied genes did not differ from the control. It is concluded that changes in gene expression of the renin-angiotensin system in brain structures of ISIAH rats may contribute to the development of hypertension.
我们研究了高血压ISIAH大鼠和正常血压WAG大鼠下丘脑和延髓中编码血管紧张素原（Agt）、肾素（Ren）、血管紧张素转换酶（ACE）和1型血管紧张素受体（AT1A）的基因表达。与WAG对照相比，年轻ISIAH大鼠下丘脑Agt mRNA量增加了30%。与WAG大鼠相比，年轻ISIAH大鼠延髓中Agt和AT1A受体的mRNA水平分别提高了60%和24%。在成年动物中，所研究基因的表达与对照无差异。得出结论，ISIAH大鼠脑结构中肾素-血管紧张素系统基因表达的变化可能有助于高血压的发展。
