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腹腔镜下切除肾细胞癌局部复发灶

Laparoscopic excision of local recurrence of renal cell carcinoma.

作者信息

Sanli Oner, Erdem Selcuk, Tefik Tzevat, Aytac Omer, Yucel Omer Baris, Oktar Tayfun, Ozcan Faruk

机构信息

Department of Urology, Istanbul Faculty of Medicine, Istanbul, Turkey.

出版信息

JSLS. 2012 Oct-Dec;16(4):597-605. doi: 10.4293/108680812X13517013316393.

Abstract

BACKGROUND AND OBJECTIVE

To report a single center's experience with laparoscopic excision of local recurrence of renal cell carcinoma.

METHODS

Between January and August 2011, 5 patients who underwent laparoscopic excision of local recurrence were identified from the institutional laparoscopic surgery database.

RESULTS

Four radical nephrectomies and 1 partial nephrectomy were performed for primary tumors. The mean ages of the patients were 57.4 y (range, 48 to 68) and 62.8 y (range, 53 to 71) at the time of primary surgery and laparoscopic recurrence excision, respectively. The average size of the primary tumor was 7.2cm (range, 4.5 to 11). The mean size of local recurrence was 3.46cm (range, 2.8 to 4.5). The original tumor T stages were T1b, T2b, and T4 in 3, 1, and 1 cases, respectively. The mean time to diagnosis of recurrence was 51.2 mo (range, 15 to 136). The pathology of one patient who had previously received targeted therapy with sunitinib, was necrosis, unlike the other 4 pathologies which revealed renal cell carcinoma. The mean operative time, estimated blood loss, and length of hospital stay were 86 min (range, 70 to 100), 100 mL (range, 20 to 300), and 4 d (range, 2 to 8), respectively. One pleural injury did not need open conversion and was repaired laparoscopically. At a mean follow-up of 8.4 mo, the cancer-specific and disease-free survival rates were 100% and 60%, respectively.

CONCLUSION

Laparoscopic excision of local recurrence of RCC is a feasible technique in well-selected patients with low-volume mass not involving the adjacent organs.

摘要

背景与目的

报告单中心腹腔镜切除肾细胞癌局部复发灶的经验。

方法

2011年1月至8月间,从机构腹腔镜手术数据库中确定5例行腹腔镜切除局部复发灶的患者。

结果

原发肿瘤行4例根治性肾切除术和1例部分肾切除术。患者初次手术和腹腔镜复发灶切除时的平均年龄分别为57.4岁(范围48至68岁)和62.8岁(范围53至71岁)。原发肿瘤平均大小为7.2cm(范围4.5至11cm)。局部复发灶平均大小为3.46cm(范围2.8至4.5cm)。原发肿瘤的T分期在3例、1例和1例中分别为T1b、T2b和T4。复发诊断的平均时间为51.2个月(范围15至136个月)。1例先前接受舒尼替尼靶向治疗的患者病理结果为坏死,与其他4例显示肾细胞癌的病理结果不同。平均手术时间、估计失血量和住院时间分别为86分钟(范围70至100分钟)、100mL(范围20至300mL)和4天(范围2至8天)。1例胸膜损伤无需转为开放手术,经腹腔镜修复。平均随访8.4个月时,癌症特异性生存率和无病生存率分别为100%和60%。

结论

对于精心挑选的、肿块体积小且未累及相邻器官的肾细胞癌局部复发患者,腹腔镜切除是一种可行的技术。

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