Chadwick E G, Connor E J, Hanson I C, Joshi V V, Abu-Farsakh H, Yogev R, McSherry G, McClain K, Murphy S B
Department of Pediatrics, Northwestern University Medical School, Chicago, Ill.
JAMA. 1990 Jun 20;263(23):3182-4.
We report the occurrence of multiple leiomyomata and leiomyosarcomata in three children with the acquired immunodeficiency syndrome. The children were infected with human immunodeficiency virus as infants (one perinatally and two through transfusions) and each was profoundly immunosuppressed (absolute CD4 cell count, less than 75/mm3). They experienced multiple infections prior to the diagnosis of neoplasms at ages 4, 5, and 8 years, respectively. The tumors in each case were mainly involving the lungs and gastrointestinal tract. The smooth-muscle origin of the tumors was proved by light and electron microscopy and immunohistochemical staining for muscle-specific actin and desmin. Leiomyomata and leiomyosarcomata are rare tumors in childhood, suggesting a nonrandom association of tumors of smooth-muscle origin and the acquired immunodeficiency syndrome. We postulate that human immunodeficiency virus infection may play a direct or indirect role in tumor formation.
我们报告了3例获得性免疫缺陷综合征患儿发生多发性平滑肌瘤和平滑肌肉瘤的情况。这些患儿在婴儿期感染了人类免疫缺陷病毒（1例通过母婴传播，2例通过输血感染），且均有严重的免疫抑制（绝对CD4细胞计数低于75/mm³）。他们分别在4岁、5岁和8岁被诊断为肿瘤之前经历了多次感染。每例患儿的肿瘤主要累及肺部和胃肠道。通过光镜、电镜以及肌肉特异性肌动蛋白和结蛋白的免疫组化染色证实了肿瘤的平滑肌起源。平滑肌瘤和平滑肌肉瘤在儿童期较为罕见，提示平滑肌起源的肿瘤与获得性免疫缺陷综合征之间存在非随机关联。我们推测人类免疫缺陷病毒感染可能在肿瘤形成中起直接或间接作用。
