智能药物输送系统：回到未来与临床现实。
Smart drug delivery systems: back to the future vs. clinical reality.
机构信息
Department of Experimental Molecular Imaging, University Clinic and Helmholtz Institute for Biomedical Engineering, RWTH - Aachen University, Aachen, Germany.
出版信息
Int J Pharm. 2013 Sep 15;454(1):527-9. doi: 10.1016/j.ijpharm.2013.02.046. Epub 2013 Feb 26.
Abstract
Recent advances in nanotechnology and material science have re-ignited interest in drug delivery research. Arguably, however, hardly any of the systems developed and strategies proposed are really relevant for shaping the future (clinical) face of the nanomedicine field. Consequently, as outlined in this commentary, instead of making ever more carrier materials, and making nanomedicine both science-fiction and fiction-science, we should try to come up with rational and realistic concepts to make nanomedicines work, in particular in patients.
摘要
近年来，纳米技术和材料科学的进展重新点燃了人们对药物输送研究的兴趣。然而，可以说，几乎没有任何已开发的系统和提出的策略与塑造纳米医学领域的未来（临床）面貌真正相关。因此，正如本评论所述，我们不应一味地制造更多的载体材料，使纳米医学既成为科幻又成为科幻科学，而应尝试提出合理和现实的概念，使纳米药物发挥作用，特别是在患者中。
相似文献
1
Smart drug delivery systems: back to the future vs. clinical reality.智能药物输送系统：回到未来与临床现实。
Int J Pharm. 2013 Sep 15;454(1):527-9. doi: 10.1016/j.ijpharm.2013.02.046. Epub 2013 Feb 26.
2
Connecting drug delivery reality to smart materials design.将药物输送的实际情况与智能材料设计联系起来。
Int J Pharm. 2013 Sep 15;454(1):521-4. doi: 10.1016/j.ijpharm.2013.04.061. Epub 2013 Apr 24.
3
Advanced drug delivery in motion.在运动中实现先进的药物输送。
Int J Pharm. 2013 Sep 15;454(1):517-20. doi: 10.1016/j.ijpharm.2013.05.002. Epub 2013 May 9.
4
Will nanomedicine deliver on its promise of changing therapeutics or remain an interesting and important research tool in cell biology and physiology?纳米医学能否兑现其改变治疗方法的承诺，还是仅仅停留在细胞生物学和生理学领域一个有趣且重要的研究工具层面？
Int J Pharm. 2013 Sep 15;454(1):530-1. doi: 10.1016/j.ijpharm.2013.06.042. Epub 2013 Jun 28.
5
Active drug targeting: lessons learned and new things to consider.主动药物靶向：经验教训和新的考虑因素。
Int J Pharm. 2013 Sep 15;454(1):525-6. doi: 10.1016/j.ijpharm.2013.03.050. Epub 2013 Apr 1.
6
Towards more effective advanced drug delivery systems.迈向更有效的高级药物输送系统。
Int J Pharm. 2013 Sep 15;454(1):496-511. doi: 10.1016/j.ijpharm.2013.02.020. Epub 2013 Feb 13.
7
In-silico simulations of advanced drug delivery systems: what will the future offer?高级药物输送系统的计算机模拟：未来将提供什么？
Int J Pharm. 2013 Sep 15;454(1):512-6. doi: 10.1016/j.ijpharm.2013.07.018. Epub 2013 Jul 16.
8
The dangers of generalization in nanotechnology.纳米技术中一概而论的危险性。
Drug Discov Today. 2004 Jan 15;9(2):60-1. doi: 10.1016/s1359-6446(03)02934-9.
9
Advances in recognitive, conductive and responsive delivery systems.识别、传导和响应递送系统的进展。
J Control Release. 2008 Dec 18;132(3):216-21. doi: 10.1016/j.jconrel.2008.06.021. Epub 2008 Jul 1.
10
Nanomedical engineering: shaping future nanomedicines.纳米医学工程：塑造未来的纳米药物。
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2015 Mar-Apr;7(2):169-88. doi: 10.1002/wnan.1315. Epub 2014 Nov 6.
引用本文的文献
1
Advanced Immunomodulatory Biomaterials for Therapeutic Applications.用于治疗应用的先进免疫调节生物材料。
Adv Healthc Mater. 2025 Feb;14(5):e2304496. doi: 10.1002/adhm.202304496. Epub 2024 May 21.
2
Ultrasonic Microbubble Cavitation Enhanced Tissue Permeability and Drug Diffusion in Solid Tumor Therapy.超声微泡空化增强实体肿瘤治疗中的组织渗透性和药物扩散
Pharmaceutics. 2022 Aug 6;14(8):1642. doi: 10.3390/pharmaceutics14081642.
3
PEGylated Liposomes Remotely Loaded with the Combination of Doxorubicin, Quinine, and Indocyanine Green Enable Successful Treatment of Multidrug-Resistant Tumors.远程负载阿霉素、奎宁和吲哚菁绿组合的聚乙二醇化脂质体能够成功治疗多药耐药肿瘤。
Pharmaceutics. 2021 Dec 17;13(12):2181. doi: 10.3390/pharmaceutics13122181.
4
Controllable Synthesis of Polymeric Micelles by Microfluidic Platforms for Biomedical Applications: A Systematic Review.用于生物医学应用的微流控平台可控合成聚合物胶束：系统综述
Iran J Pharm Res. 2021 Spring;20(2):229-240. doi: 10.22037/ijpr.2021.114226.14769.
5
Applications of nanomaterials in COVID-19 pandemic.纳米材料在新冠疫情中的应用。
Rare Metals. 2022;41(1):1-13. doi: 10.1007/s12598-021-01789-y. Epub 2021 Sep 15.
6
Harnessing Endogenous Stimuli for Responsive Materials in Theranostics.内源性刺激在治疗诊断学中响应性材料的应用。
ACS Nano. 2021 Feb 23;15(2):2068-2098. doi: 10.1021/acsnano.0c09115. Epub 2021 Feb 8.
7
Micro/nano-bubble-assisted ultrasound to enhance the EPR effect and potential theranostic applications.微/纳米气泡辅助超声增强 EPR 效应及其潜在的治疗应用。
Theranostics. 2020 Jan 1;10(2):462-483. doi: 10.7150/thno.37593. eCollection 2020.
8
Nanopharmaceuticals and nanomedicines currently on the market: challenges and opportunities.市售的纳米药物和纳米医药：挑战与机遇。
Nanomedicine (Lond). 2019 Jan;14(1):93-126. doi: 10.2217/nnm-2018-0120. Epub 2018 Nov 19.
9
Current Trends and Challenges in the Clinical Translation of Nanoparticulate Nanomedicines: Pathways for Translational Development and Commercialization.纳米颗粒纳米药物临床转化的当前趋势与挑战：转化发展与商业化途径
Front Pharmacol. 2018 Jul 17;9:790. doi: 10.3389/fphar.2018.00790. eCollection 2018.
10
Cellular interaction of a layer-by-layer based drug delivery system depending on material properties and cell types.基于层层递药系统的细胞相互作用取决于材料性质和细胞类型。
Int J Nanomedicine. 2018 Apr 5;13:2079-2091. doi: 10.2147/IJN.S153701. eCollection 2018.
本文引用的文献
1
Towards more effective advanced drug delivery systems.迈向更有效的高级药物输送系统。
Int J Pharm. 2013 Sep 15;454(1):496-511. doi: 10.1016/j.ijpharm.2013.02.020. Epub 2013 Feb 13.
Zotero 插件