Department Molecules-Signaling-Development, Max Planck Institute of Neurobiology, Martinsried D-82152, Germany.
Trends Neurosci. 2013 May;36(5):295-304. doi: 10.1016/j.tins.2013.01.007. Epub 2013 Feb 26.
Growing axons are exposed to various guidance cues en route to their targets. Although many guidance molecules have been identified and their effects on axon behavior extensively studied, how axons react to combinations of signals remains largely unexplored. We review recent studies investigating the combined actions of guidance cues present at the same choice points. Two main scenarios are emerging from these studies: parallel signaling and crosstalk between guidance systems. In the first case, cues act in an additive manner, whereas in the second case the outcome is non-additive and differs from the sum of individual effects, suggesting more complex signal integration in the growth cone. Some of the molecular mechanisms underlying these interactions are beginning to be unraveled.
生长轴突在到达靶标时会接触到各种导向线索。尽管已经鉴定出许多导向分子，并广泛研究了它们对轴突行为的影响，但轴突如何对信号组合做出反应在很大程度上仍未得到探索。我们回顾了最近研究同一选择点存在的导向线索的联合作用的研究。这些研究出现了两种主要情况：信号的平行传递和导向系统之间的串扰。在前一种情况下，线索以相加的方式起作用，而在后一种情况下，结果是非相加的，不同于各个效应的总和，这表明在生长锥中存在更复杂的信号整合。这些相互作用的一些分子机制开始被揭示。
