Fujito K
Department of Medicine, Juntendo University School of Medicine, Bunkyo-ku.
Nihon Jinzo Gakkai Shi. 1990 Jan;32(1):45-51.
The purpose of the study was to determine the effect of dietary calcium intake on blood pressure and sodium ion transport of red blood cells (RBC) in spontaneously hypertensive rats (SHR). The SHR were fed by diet with three different levels of calcium contents as follows; 0.1% of Ca (low Ca diet), 0.6% of Ca (normal Ca diet) and 4.0% of Ca (high Ca diet) between 6 and 20 weeks of age. At 20 weeks of age, the levels of erythrocyte sodium efflux, as well as sodium and potassium contents in the RBC were measured. On the low calcium diet, SHR showed an enhancement of hypertension. On the high calcium diet, SHR showed an attenuation of the increase in blood pressure. In proportion to the levels of dietary calcium contents, SHR had a lower level of sodium contents in the RBC and a higher activity of the sodium pump. The passive sodium permeability and sodium-potassium cotransport in SHR were similar among low, normal and high calcium diet groups. It is concluded that the amounts of dietary calcium might be related to the regulation of blood pressure by changing the sodium pump of the cell membrane in SHR.
本研究的目的是确定膳食钙摄入量对自发性高血压大鼠（SHR）血压及红细胞（RBC）钠离子转运的影响。在6至20周龄期间，给SHR喂食钙含量有三种不同水平的日粮，分别如下：0.1%钙（低钙日粮）、0.6%钙（正常钙日粮）和4.0%钙（高钙日粮）。在20周龄时，测量红细胞钠外流水平以及RBC中的钠和钾含量。低钙日粮组的SHR高血压加剧。高钙日粮组的SHR血压升高情况有所减轻。与膳食钙含量水平成比例，SHR的RBC中钠含量较低，钠泵活性较高。低钙、正常钙和高钙日粮组的SHR被动钠通透性和钠钾协同转运相似。得出的结论是，膳食钙的量可能通过改变SHR细胞膜的钠泵与血压调节有关。
