Department of Psychology, University of Tromsø, Tromsø, Norway.
OOO "NPF "Materia Medica Holding", Moscow, Russia.
Int J Impot Res. 2014 Jan;26(1):35-40. doi: 10.1038/ijir.2013.12. Epub 2013 Mar 14.
Endothelial nitric oxide synthase (eNOS) has an important role in erection, and it also affects aspects of sexual behavior. In this experiment, we determined whether a compound enhancing the activity of eNOS, Impaza, could stimulate any aspect of sexual behavior and increase penis length in rats with a high baseline of sexual activity. For comparison, the PDE5 inhibitor sildenafil was included. Male rats were orally treated with Impaza or sildenafil for 28 days. Impaza (3 ml kg(-1)) was given daily while sildenafil (3 mg kg(-1)) was given twice weekly. Tests for sexual incentive motivation and copulatory behavior were performed just before drug treatment and at days 7, 14 and 28 of treatment. In addition, the length of the protruding penis at mount, intromission and ejaculation was measured. Impaza but not sildenafil increased penis length at mount after 14 and 28 days of treatment. The compounds failed to modify sexual incentive motivation or copulatory behavior. It is suggested that Impaza enhanced intracavernous pressure, as such a pressure increase is the most likely explanation for enhanced penis length at mount. This effect, together with an absence of motivational actions, suggests that Impaza may be the most valuable treatment for erectile dysfunction.
内皮型一氧化氮合酶（eNOS）在勃起中起着重要作用，它也影响性行为的各个方面。在本实验中，我们确定了一种增强 eNOS 活性的化合物 Impaza 是否可以刺激任何性行为方面，并增加具有高基线性活动的大鼠的阴茎长度。为了进行比较，还包括了 PDE5 抑制剂西地那非。雄性大鼠经口给予 Impaza 或西地那非治疗 28 天。Impaza（3ml/kg）每天给予一次，而西地那非（3mg/kg）每周给予两次。在药物治疗前以及治疗第 7、14 和 28 天进行性动机和交配行为测试。此外，还测量了在勃起、插入和射精时阴茎的突出长度。经过 14 天和 28 天的治疗，Impaza 而非西地那非增加了勃起时的阴茎长度。这些化合物未能改变性动机或交配行为。这表明 Impaza 增强了海绵体内压，因为这种压力的增加最有可能解释勃起时阴茎长度的增加。这种效果，再加上缺乏动机作用，表明 Impaza 可能是治疗勃起功能障碍最有价值的治疗方法。
