Karsanov N V, Melashvili N O, Khugashvili Z G, Mamulashvili L D, Azrumelashvili M I, Khaindrava G K, Kapanadze R V
Kardiologiia. 1990 Feb;30(2):81-7.
In experiments on dogs, the authors examined the functional activity of three cardiomyocyte systems responsible for contraction-relaxation (the systems of contractile proteins, calcium transport and energy supply) in the dynamics of L-thyroxine-induced toxicosis. A fall in the capacity of the contractile protein system to generate energy and to perform was shown to play the leading role in decrease of myocardial reserve forces and reduction in cardiac contractility. There was a drop in the intensity of calcium transport through the membranes of the sarcoplasmic reticulum and mitochondria and a deficiency of the direct energy source for contraction only in the late period of the disease.
在对狗的实验中，作者研究了在L-甲状腺素诱导的中毒过程中，负责收缩-舒张的三个心肌细胞系统（收缩蛋白系统、钙转运系统和能量供应系统）的功能活性。收缩蛋白系统产生能量和发挥功能的能力下降，在心肌储备力降低和心脏收缩力减弱中起主导作用。只有在疾病后期，肌浆网和线粒体膜的钙转运强度才会下降，且收缩的直接能量来源出现不足。
