肺纤维化中肺间充质多能基质细胞的分化
Differentiation of mesenchymal multipotent stromal cells of the lungs in pneumofibrosis.
作者信息
Skurikhin E G, Khmelevskaya E S, Pershina O V, Ermakova N N, Krupin V A, Reztsova A M, Ermolaeva L A, Yakushina V D, Stepanova I E, Reztsova V M, Cherdyntseva N V, Stakheeva M N, Dygai A M
机构信息
Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia.
出版信息
Bull Exp Biol Med. 2013 Feb;154(4):537-43. doi: 10.1007/s10517-013-1995-6.
We studied differentiation of multipotent mesenchymal stromal cells (MMSC) of the lungs of C57Bl/6 mice with bleomycin-induced pneumofibrosis. Adherent mononuclear cells found in mouse lungs demonstrated mesenchymal phenotype and expressed CD44, CD73, CD90, and CD106, but not CD31, CD34, and CD45. The cells with MMSC characteristics differentiate in vitro into various cells of stromal lines (chondrocytes, osteogenic cells, adipocytes, and fibroblasts). Bleomycin increased the growth rate of MMSC and selectively promoted their differentiation towards fibroblast cells.
我们研究了博来霉素诱导肺纤维化的C57Bl/6小鼠肺脏多能间充质基质细胞（MMSC）的分化情况。在小鼠肺脏中发现的贴壁单核细胞表现出间充质表型，表达CD44、CD73、CD90和CD106，但不表达CD31、CD34和CD45。具有MMSC特征的细胞在体外可分化为多种基质系细胞（软骨细胞、成骨细胞、脂肪细胞和成纤维细胞）。博来霉素提高了MMSC的生长速率，并选择性地促进它们向成纤维细胞分化。
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