双生子研究中观察者间一致性的校正推断程序。

Adjusted inference procedures for the interobserver agreement in twin studies.

作者信息

Dixon Stephanie N, Donner Allan, Shoukri Mohamed M

机构信息

Department of Epidemiology and Biostatistics, Western University, London, ON, Canada Division of Nephrology, Department of Medicine, London Health Science Centre and Western University, London, ON, Canada

Department of Epidemiology and Biostatistics, Western University, London, ON, Canada.

出版信息

Stat Methods Med Res. 2016 Aug;25(4):1260-71. doi: 10.1177/0962280213476771. Epub 2013 Mar 12.

DOI:10.1177/0962280213476771

PMID:23487017

Abstract

We propose adjusted inference procedures for evaluating the agreement/disagreement of two raters in a clustered setting involving twins or paired body parts. These procedures include the construction of a confidence interval for the kappa statistic, a related test of statistical significance and a formula that facilitates sample size estimation. The results of a simulation study suggest that a simple adjustment using an estimated design effect will provide valid inferences. The methods proposed are illustrated using an example from the literature.

摘要

我们提出了调整后的推断程序，用于评估在涉及双胞胎或成对身体部位的聚类环境中两位评分者的一致性/不一致性。这些程序包括构建kappa统计量的置信区间、相关的统计显著性检验以及有助于样本量估计的公式。一项模拟研究的结果表明，使用估计的设计效应进行简单调整将提供有效的推断。通过文献中的一个例子说明了所提出的方法。