Lin Pei Ru, Zhao Zi Wen, Cheng Kar-Keung, Lam Tai-Hing
Guangzhou First Municipal Peoples Hospital, Guangzhou Medical University, Guangzhou, China.
J Public Health (Oxf). 2013 Sep;35(3):375-83. doi: 10.1093/pubmed/fdt018. Epub 2013 Mar 13.
To study the effectiveness of a very brief advice (<30 s) on smoking cessation.
A 'proof-of-principle' single-blind, randomized controlled trial (RCT).
Medical outpatient clinics of a general hospital in Guangzhou, China.
One hundred and twenty-six male current smokers randomly allocated into an intervention (n = 74) and a control group (n = 52). Intervention A health warning by physicians that half of all smokers would be killed by smoking, an advice to quit immediately and referral to a cessation clinic. The control group received none.
Primary: seven-day quitting point prevalence at 6 months. Secondary: 7-day point prevalence at 1, 3 and 12 months, sustained abstinence at 3, 6 and 12 months, smoking reduction by half and cessation clinic attendance.
By intention-to-treat analysis, 7-day quitting point prevalence rates at four follow-ups were 27.0, 23.0, 21.6 and 18.9% in the intervention group, compared with 5.8, 3.8, 5.8 and 5.8% in the control group (first three P < 0.05). At 3, 6 and 12 months, sustained abstinence prevalence rates were 18.9, 17.6 and 14.9% versus 3.8, 3.8 and 3.8% (P = 0.035, 0.046, 0.074). More smokers in the intervention group had reduced smoking. Almost no participants attended the cessation clinic.
Our findings support the need for large RCTs on minimal interventions with the 'one in two' warning.
研究极简短戒烟建议（<30秒）的有效性。
一项“原理验证”单盲随机对照试验（RCT）。
中国广州一家综合医院的门诊。
126名男性现吸烟者被随机分为干预组（n = 74）和对照组（n = 52）。干预组 医生发出健康警告，告知所有吸烟者中有一半会因吸烟而死亡，建议立即戒烟并转介至戒烟门诊。对照组未接受任何干预。
主要指标：6个月时7天戒烟点患病率。次要指标：1、3和12个月时的7天点患病率、3、6和12个月时的持续戒烟率、吸烟量减半以及戒烟门诊就诊情况。
采用意向性分析，干预组在四次随访时的7天戒烟点患病率分别为27.0%、23.0%、21.6%和18.9%，而对照组分别为5.8%、3.8%、5.8%和5.8%（前三次P<0.05）。在3、6和12个月时，持续戒烟患病率分别为18.9%、17.6%和14.9%，而对照组分别为3.8%、3.8%和3.8%（P = 0.035、0.046、0.074）。干预组中更多吸烟者减少了吸烟量。几乎没有参与者前往戒烟门诊就诊。
我们的研究结果支持有必要开展大型随机对照试验，以研究“两人中有一人”警告这一最小干预措施的效果。
