Aydın Funda, Kın Cengiz Arzu, Güngör Fırat
Akdeniz University Medical School, Department of Nuclear Medicine, Antalya, Turkey.
Mol Imaging Radionucl Ther. 2012 Apr;21(1):13-8. doi: 10.4274/Mirt.165. Epub 2012 Apr 1.
(99m)Tc labeled hexamethylpropylene amine oxime (HMPAO) white blood cell (WBC) scintigraphy is a frequently used option for acute infection, particularly in pediatric patients. This scintigraphy is applied to detect sites of infection/inflammation in patients with fever of unknown origin, to find and follow up osteomyelitis, and to detect suspicion of acute appendicitis. The aim of this retrospective study was to evaluate the value of (99m)Tc-HMPAO labeled WBC scintigraphy in pediatric patients.
The study was conducted between January 2006 and December 2008 and included 13 patients (5 boys, 8 girls; mean age 6.9±6.2 years). Those patients who had suspicion of bone infection (n=7), fever of unknown origin (n=3), and suspicion of acute appendicitis (n=3) were evaluated retrospectively. (99m)Tc-HMPAO labeled WBC scintigraphy imaging was performed to all patients. Diagnosis was done according to operation and pathological results or clinical follow-up.
(99m)Tc-HMPAO labeled WBC scintigraphy has been found to be true positive in 6 cases, true negative in 6 cases, and false negative in one patient who had fewer unknown origin. The false negative case has been found to have encephalitis with MRI.
Leukocyte scintigraphy has been described as a useful diagnostic tool in the diagnosis of suspicion of bone infection, fever of unknown origin and suspicion of acute appendicitis. (99m)Tc-HMPAO labeled WBC scintigraphy is a rapid and very accurate method for detecting those pathologies. Our results showed that WBC scintigraphy might be reliably used for diagnosis of suspected bone infection and acute appendicitis, fever of unknown origin, and acute appendicitis, in pediatric patient population.
None declared.
锝-99m（99mTc）标记的六甲基丙烯胺肟（HMPAO）白细胞（WBC）闪烁扫描术是急性感染常用的检查方法，尤其适用于儿科患者。该闪烁扫描术用于检测不明原因发热患者的感染/炎症部位，查找并随访骨髓炎，以及检测疑似急性阑尾炎。这项回顾性研究的目的是评估99mTc-HMPAO标记的WBC闪烁扫描术在儿科患者中的价值。
研究于2006年1月至2008年12月进行，纳入13例患者（5例男孩，8例女孩；平均年龄6.9±6.2岁）。对怀疑有骨感染（n=7）、不明原因发热（n=3）和疑似急性阑尾炎（n=3）的患者进行回顾性评估。对所有患者进行99mTc-HMPAO标记的WBC闪烁扫描成像。根据手术及病理结果或临床随访做出诊断。
99mTc-HMPAO标记的WBC闪烁扫描术在6例中为真阳性，6例为真阴性，1例不明原因发热患者为假阴性。经磁共振成像（MRI）检查发现该假阴性病例患有脑炎。
白细胞闪烁扫描术被认为是诊断疑似骨感染、不明原因发热和疑似急性阑尾炎的有用诊断工具。99mTc-HMPAO标记的WBC闪烁扫描术是检测这些病变的快速且非常准确的方法。我们的结果表明，WBC闪烁扫描术可可靠地用于儿科患者疑似骨感染、不明原因发热和急性阑尾炎的诊断。
未声明。
