Cohen J S
Department of Ophthalmology, College of Medicine, University of Cincinnati, OH.
Ophthalmic Surg. 1990 Mar;21(3):181-6.
In this preliminary retrospective study, results of combined extracapsular cataract extraction, intraocular lens implantation, and filtering surgery with subconjunctival 5-fluorouracil (5-FU) injections in 22 eyes were compared with those obtained in a similar group without 5-FU injections. Five to 35 mg (mean, 17.3 mg) of 5-FU were administered to each eye in the 5-FU group. Intraocular pressure (IOP) was controlled with fewer medications postoperatively than preoperatively in both the 5-FU group and the control group. However, the 5-FU group demonstrated statistically significant greater improvement in IOP control than the control group (P = .043).
在这项初步回顾性研究中，将22只眼行白内障囊外摘除术、人工晶状体植入术以及结膜下注射5-氟尿嘧啶（5-FU）的滤过手术的结果，与类似的未注射5-FU组的结果进行比较。5-FU组每只眼给予5至35毫克（平均17.3毫克）的5-FU。5-FU组和对照组术后眼压（IOP）均比术前用更少的药物得到控制。然而，5-FU组在眼压控制方面的改善在统计学上显著优于对照组（P = 0.043）。
