J Biol Regul Homeost Agents. 2013 Jan-Mar;27(1):1-7.
Inflammation is involved in increasing number of diseases necessitating the development of new, effective and safe treatments. Non steroidal anti-inflammatory drugs (NSAIDs) have been helpful in many instances, but they only inhibit cyclooxygenase (COX), but not the generation or actions of cytokines. Instead, some natural flavonoids have multiple anti-inflammatory effects, including COX inhibition, and a much safer profile. Increasing evidence indicates that inflammation plays a critical role in the pathogenesis of many diseases that also involve mast cells. Consequently, the need for new, effective and safe anti-inflammatory drugs is all the more urgent. Corticosteroids are quite potent, but have many adverse effects such as increased risk of infections, osteoporosis, glaucoma and depression. Biological agents such anti-TNF are useful in certain conditions, such as rheumatoid arthritis and psoriasis, but has been associated with increased risk of infection and leukemia.
炎症与越来越多的疾病有关，需要开发新的、有效和安全的治疗方法。非甾体抗炎药（NSAIDs）在许多情况下都有帮助，但它们只能抑制环氧化酶（COX），而不能抑制细胞因子的产生或作用。相反，一些天然类黄酮具有多种抗炎作用，包括 COX 抑制作用，且安全性更高。越来越多的证据表明，炎症在许多疾病的发病机制中起着关键作用，这些疾病也涉及肥大细胞。因此，对新的、有效和安全的抗炎药物的需求更加迫切。皮质类固醇非常有效，但有许多不良反应，如感染风险增加、骨质疏松症、青光眼和抑郁症。抗 TNF 等生物制剂在某些情况下（如类风湿关节炎和银屑病）很有用，但与感染和白血病风险增加有关。
