无碱基寡脱氧核糖核苷硫代磷酸酯：作为抗HIV-1药物的合成与评价
Abasic oligodeoxyribonucleoside phosphorothioates: synthesis and evaluation as anti-HIV-1 agents.
作者信息
Iyer R P, Uznanski B, Boal J, Storm C, Egan W, Matsukura M, Broder S, Zon G, Wilk A, Koziolkiewicz M
机构信息
Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD.
出版信息
Nucleic Acids Res. 1990 May 25;18(10):2855-9. doi: 10.1093/nar/18.10.2855.
Abstract
The syntheses and anti-HIV-1 evaluations of two, abasic oligodeoxyribonucleotide phosphorothioate analogs, d[Cps(Eps)26C] and d[Cps(Vps)26C] (where E and V derive from 1,2-dideoxy-D-ribofuranose and (+/-)-butane 1, 3-diol, respectively), are described.
摘要
描述了两种无碱基寡脱氧核糖核苷酸硫代磷酸酯类似物d[Cps(Eps)26C]和d[Cps(Vps)26C]（其中E和V分别源自1,2-二脱氧-D-核糖呋喃糖和(+/-)-丁烷1,3-二醇）的合成及抗HIV-1活性评估。
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