Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Tiantan Xili 6, Dongcheng District, Beijing, 100050, People's Republic of China.
J Neurooncol. 2013 Jun;113(2):251-8. doi: 10.1007/s11060-013-1102-x. Epub 2013 Mar 15.
This study was designed to find whether long-term survivors (LTSs) exhibit molecular genetic differences compared with short-term survivors (STSs) in patients with GBM. Tumors from 12 patients initially diagnosed with GBM and survived longer than 36 months (LTSs) were compared with 30 patients with GBM and STSs (survival <18 months) for detecting of MGMT promoter methylation, 1p/19q LOH and IDH1 mutation. IDH1 mutation and MGMT promoter methylation were significantly more frequent in the LTSs group (P = 0.039 and 0.017, respectively). The incidence of 1p/19q co-deletion was not significantly different (P = 1.0). IDH1 mutation and MGMT promoter methylation might be independent, significant, and favorable factors for LTSs with GBM.
本研究旨在探讨胶质母细胞瘤（GBM）患者中，长期幸存者（LTSs）与短期幸存者（STSs）是否存在分子遗传学差异。将 12 例初诊为 GBM 且生存时间超过 36 个月（LTSs）的患者的肿瘤与 30 例生存时间<18 个月的 GBM STSs 患者进行比较，以检测 MGMT 启动子甲基化、1p/19q LOH 和 IDH1 突变。LTSs 组中 IDH1 突变和 MGMT 启动子甲基化的发生率明显更高（P = 0.039 和 0.017）。1p/19q 共缺失的发生率无显著差异（P = 1.0）。IDH1 突变和 MGMT 启动子甲基化可能是胶质母细胞瘤 LTSs 的独立、显著和有利因素。
