Adam Mickiewicz University, Institute of Physics, Umultowska 85, 61-614 Poznańn, Poland.
Expert Opin Drug Discov. 2007 Feb;2(2):225-48. doi: 10.1517/17460441.2.2.225.
In this review, fundamentals of nuclear quadrupole resonance (NQR) spectroscopy are briefly outlined. Examples of its applications in drug development are discussed to demonstrate that the NQR method is a sophisticated, non-destructive and valuable analytical technique for studying pharmaceuticals, providing effective assistance at the two main steps of drug development: the physical and chemical characterization of the active pharmaceutical ingredients (API) at the analytical step and API development. This review covers different aspects of the use of NQR spectroscopy for drug development and analysis and illustrates the power and versatility of this method in the determination of impurities, polymorphic forms, the drug's structure and conformation, characterization of the interactions between the drug and ligands, search for analogs (second- or third-generation drugs) and the drug's thermal stability. Lastly, NQR advantages and restrictions in the aspect of application in drug development studies are summarized.
在这篇综述中，简要概述了核四极矩共振（NQR）光谱学的基本原理。讨论了其在药物开发中的应用实例，以证明 NQR 方法是一种复杂、非破坏性和有价值的分析技术，可用于研究药物，在药物开发的两个主要步骤中提供有效帮助：在分析步骤中对原料药（API）的物理和化学特性进行表征，以及 API 的开发。本综述涵盖了 NQR 光谱法在药物开发和分析中的不同应用方面，并说明了该方法在确定杂质、多晶型形式、药物结构和构象、药物与配体相互作用的表征、寻找类似物（第二代或第三代药物）以及药物热稳定性方面的强大功能和多功能性。最后，总结了 NQR 在药物开发研究应用方面的优势和局限性。
