Nakae Y, Goto N, Nara T
Department of Pediatrics, Jikei University School of Medicine, Tokyo, Japan.
Acta Anat (Basel). 1990;137(3):272-7. doi: 10.1159/000146831.
The development of the human putamen was studied using complete serial sections from the brains of 6 fetuses at 21, 23, 27, 30, 33 and 34 weeks of gestation (WG). Morphometric analysis revealed the following data. (1) The total number of putaminal neurons increased gradually from 21 to 33 WG, suggesting that the migration of putaminal neurons continues at least up to 33 WG, and the neuronal number increased markedly after 33 WG. (2) No neuronal death was observed from 21 to 34 WG. (3) Large-sized neurons 4-5 times the area of small-sized neurons appeared from 30 WG onward. The ratio of large neurons to the total putaminal neurons increased by up to 1.4% at 33 and 34 WG.
利用来自6例妊娠21、23、27、30、33和34周（WG）胎儿大脑的完整连续切片，对人类壳核的发育进行了研究。形态计量学分析得出以下数据。（1）壳核神经元总数从妊娠21周逐渐增加至33周，这表明壳核神经元的迁移至少持续到33周，且在33周后神经元数量显著增加。（2）在妊娠21周至34周未观察到神经元死亡。（3）从妊娠30周起出现了面积为小神经元4 - 5倍的大神经元。在妊娠33周和34周时，大神经元占壳核神经元总数的比例增加至1.4%。
