Niederkorn J, Sanborn G E, Scarbrough E E
Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas 75235-9057.
Arch Ophthalmol. 1990 Jun;108(6):865-8. doi: 10.1001/archopht.1990.01070080109045.
The efficacy of brachytherapy in the treatment and prevention of metastasis of intraocular melanoma was investigated in a mouse model. A highly metastatic subline of B16 melanoma was transplanted into the anterior segment of C57BL/6 mice and allowed to grow. Brachytherapy was delivered by means of miniature iodine 125 seeds implanted in shallow subcutaneous pockets of the upper eyelid margin of these mice, and 25 Gy of radiation was delivered between days 12 and 14. This brachytherapy reduced both the tumor volume and the number of mitotic figures per high-power field compared with irradiated controls. In a second experiment, 25 Gy of brachytherapy was delivered before enucleation, straddling enucleation, and after enucleation; there was a significant reduction in metastasis when radiation was delivered prior to enucleation. This model may be useful in conducting further studies involving brachytherapy with 125I plaque implants.
在小鼠模型中研究了近距离放射疗法在治疗和预防眼内黑色素瘤转移方面的疗效。将具有高转移性的B16黑色素瘤亚系移植到C57BL/6小鼠的眼前段并使其生长。通过将微型碘125种子植入这些小鼠上睑缘的浅皮下囊中来进行近距离放射疗法，并在第12天至第14天之间给予25 Gy的辐射。与接受辐射的对照组相比，这种近距离放射疗法减少了肿瘤体积和每高倍视野中的有丝分裂象数量。在第二项实验中，在眼球摘除前、眼球摘除期间和眼球摘除后给予25 Gy的近距离放射疗法；在眼球摘除前给予辐射时，转移明显减少。该模型可能有助于开展涉及125I斑块植入近距离放射疗法的进一步研究。
