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[哥伦比亚血库中输血传播感染标志物的血清流行率]

[Seroprevalence of markers of transfusion transmissible infections in blood bank in Colombia].

作者信息

Bedoya Jair Alberto Patiño, Cortés Márquez Mónica María, Cardona Arias Jaiberth Antonio

机构信息

Escuela de Microbiología, Universidad de Antioquia, Medellín, Colombia.

出版信息

Rev Saude Publica. 2012 Dec;46(6):950-9.

Abstract

OBJECTIVE

To determine the seroprevalence of markers of transfusion transmissible infections in donors of a blood bank in Medellin, Colombia, beteween 2007 and 2010.

METHODS

A cross-sectional secondary data source, based on the results of biological testing of donors to a blood bank in Medellin. We determined the seroprevalence of markers of infection and were compared by sex and type of donor through frequency analysis, chi square, Fisher and prevalence ratios.

RESULTS

The base population was 65,535 donors, and 3.3% had at least one positive biological test. The most prevalent marker in the blood bank testing was syphilis (1,2%), followed by trypanosomiasis (1,0%), hepatitis C virus (HCV) (0,6%), human immunodeficiency virus (HIV) 0,5% and hepatitis B virus (HBV) (0,2%). Based on the reference laboratory found a prevalence of 0.6% for syphilis, 0,1% for (HBV) and 0% for (HCV), (HIV) and Chagas. We found statistical differences in the prevalence of (HBV) and syphilis by sex and type of donor.

CONCLUSIONS

The results are consistent with the prevalences given by Pan American Health Organization and can be correlated with the global prevalence of transfusion-transmitted infections. The results founds by the blood bank lead to a transfusion risk reduction but limit the optimization of resources by excluding donors classified as false positives.

摘要

目的

确定2007年至2010年期间哥伦比亚麦德林一家血库献血者中输血传播感染标志物的血清流行率。

方法

基于麦德林一家血库献血者生物学检测结果的横断面二手数据源。我们确定了感染标志物的血清流行率,并通过频率分析、卡方检验、费舍尔检验和流行率比按性别和献血者类型进行比较。

结果

基础人群为65535名献血者,3.3%的人至少有一项生物学检测呈阳性。血库检测中最常见的标志物是梅毒(1.2%),其次是锥虫病(1.0%)、丙型肝炎病毒(HCV)(0.6%)、人类免疫缺陷病毒(HIV)0.5%和乙型肝炎病毒(HBV)(0.2%)。根据参考实验室的数据,梅毒的流行率为0.6%,HBV为0.1%,HCV、HIV和恰加斯病为0%。我们发现HBV和梅毒的流行率在性别和献血者类型方面存在统计学差异。

结论

结果与泛美卫生组织给出的流行率一致,并且可以与输血传播感染的全球流行率相关联。血库的检测结果降低了输血风险,但由于排除了被归类为假阳性的献血者,限制了资源的优化。

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