Analytical Chemistry Department, GUIA Group, I3A, EINA, University of Zaragoza, Zaragoza, Spain.
Anal Bioanal Chem. 2013 May;405(14):4747-54. doi: 10.1007/s00216-013-6881-6. Epub 2013 Mar 16.
The identification of unknown non-volatile migrant compounds from adhesives used in food contact materials is a very challenging task because of the number of possible compounds involved, given that adhesives are complex mixtures of chemicals. The use of ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (UPLC-MS/QTOF) is shown to be a successful tool for identifying non-targeted migrant compounds from two hot melt adhesives used in food packaging laminates. Out of the seven migrants identified and quantified, five were amides and one was a compound classified in Class II of the Cramer toxicity. None of the migration values exceeded the recommended Cramer exposure values.
从食品接触材料用胶粘剂中识别未知的非挥发性迁移化合物是一项极具挑战性的任务，因为胶粘剂是化学物质的复杂混合物，所以涉及的可能化合物的数量众多。研究表明，超高效液相色谱-四极杆飞行时间质谱联用（UPLC-MS/QTOF）可成功用于鉴定两种用于食品包装层压材料的热熔胶中的非靶向迁移化合物。在所鉴定和定量的 7 种迁移物中，有 5 种为酰胺，1 种为 Cramer 毒性分类 II 类化合物。迁移值均未超过推荐的 Cramer 暴露值。
