Perrar K M, Golla H, Voltz R
Zentrum für Palliativmedizin, Uniklinik Köln, Kerpener Strasse 62, Köln, Germany.
Schmerz. 2013 Apr;27(2):190-8. doi: 10.1007/s00482-013-1293-2.
This systematic literature review aims to collect and analyse relevant clinical trials for the drug treatment of delirium in palliative care. The search was conducted including July 2012 in Medline (from 1966) and Embase (from 1974). The search retrieved 448 studies, of which 3 studies could be included in the analysis. Treatment with the antipsychotic drug haloperidol can be recommended, which is also true to a somewhat lower extent for the antipsychotics olanzapine and aripiprazole. Treatment with lorazepam only should be avoided. This literature analysis reflects the positive clinical experience, especially when using haloperidol. To confirm these recommendations, further substantial clinical studies are needed.The English full-text version of this article can be found at SpringerLink (under "Supplemental").
本系统文献综述旨在收集并分析姑息治疗中谵妄药物治疗的相关临床试验。检索范围包括2012年7月之前的Medline（始于1966年）和Embase（始于1974年）。检索共获得448项研究，其中3项研究可纳入分析。可推荐使用抗精神病药物氟哌啶醇进行治疗，抗精神病药物奥氮平和阿立哌唑在一定程度上也适用。应避免仅使用劳拉西泮进行治疗。该文献分析反映了积极的临床经验，尤其是使用氟哌啶醇时。为证实这些建议，还需要进一步大量的临床研究。本文的英文全文版本可在SpringerLink（“补充材料”项下）获取。
