• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Comment on the article "physiologically based modeling of pravastatin transporter-mediated hepatobiliary disposition and drug-drug interactions".

作者信息

Neuhoff Sibylle, Tucker Geoff T

出版信息

Pharm Res. 2013 Jun;30(6):1467-8. doi: 10.1007/s11095-013-0988-5. Epub 2013 Mar 16.

DOI:10.1007/s11095-013-0988-5
PMID:23504339
Abstract
摘要

相似文献

1
Comment on the article "physiologically based modeling of pravastatin transporter-mediated hepatobiliary disposition and drug-drug interactions".
Pharm Res. 2013 Jun;30(6):1467-8. doi: 10.1007/s11095-013-0988-5. Epub 2013 Mar 16.
2
Response to the comment on the article "physiologically based modeling of pravastatin transporter-mediated hepatobiliary disposition and drug-drug interactions".对文章《基于生理学的普伐他汀转运体介导的肝胆处置及药物-药物相互作用建模》评论的回应
Pharm Res. 2013 Jun;30(6):1469-70. doi: 10.1007/s11095-013-0987-6. Epub 2013 Mar 6.
3
Physiologically based modeling of pravastatin transporter-mediated hepatobiliary disposition and drug-drug interactions.基于生理学的普伐他汀转运体介导的肝胆处置和药物相互作用的建模。
Pharm Res. 2012 Oct;29(10):2860-73. doi: 10.1007/s11095-012-0792-7. Epub 2012 May 26.
4
Physiologically based pharmacokinetic modeling to predict transporter-mediated clearance and distribution of pravastatin in humans.基于生理的药代动力学建模以预测普伐他汀在人体内由转运体介导的清除率和分布情况。
J Pharmacol Exp Ther. 2009 Feb;328(2):652-62. doi: 10.1124/jpet.108.146647. Epub 2008 Nov 10.
5
Prediction of the Pharmacokinetics of Pravastatin as an OATP Substrate Using Plateable Human Hepatocytes With Human Plasma Data and PBPK Modeling.利用可平板培养的人源肝细胞和人血浆数据以及 PBPK 模型预测普伐他汀作为 OATP 底物的药代动力学。
CPT Pharmacometrics Syst Pharmacol. 2018 Apr;7(4):251-258. doi: 10.1002/psp4.12283. Epub 2018 Feb 13.
6
Human liver-specific organic anion transporter, LST-1, mediates uptake of pravastatin by human hepatocytes.人类肝脏特异性有机阴离子转运体LST-1介导普伐他汀被人肝细胞摄取。
J Pharmacol Exp Ther. 2001 Jun;297(3):861-7.
7
The role of hepatic transport and metabolism in the interactions between pravastatin or repaglinide and two rOatp inhibitors in rats.肝脏转运和代谢在普伐他汀或瑞格列奈与两种大鼠 rOatp 抑制剂相互作用中的作用。
Eur J Pharm Sci. 2013 Jul 16;49(4):767-72. doi: 10.1016/j.ejps.2013.04.030. Epub 2013 May 3.
8
[Effect of pravastatin on transportation of scutellarin in mouse liver and its mechanism].[普伐他汀对灯盏花素在小鼠肝脏中转运的影响及其机制]
Yao Xue Xue Bao. 2011 Mar;46(3):269-73.
9
Culture period-dependent changes in the uptake of transporter substrates in sandwich-cultured rat and human hepatocytes.贴壁培养的大鼠和人肝细胞对转运体底物摄取的文化期依赖性变化。
Drug Metab Dispos. 2011 Sep;39(9):1503-10. doi: 10.1124/dmd.111.038968. Epub 2011 Jun 14.
10
Effects of High-cholesterol Diet on Pravastatin Disposition in the Perfused Rat Liver.高胆固醇饮食对普伐他汀在灌注大鼠肝脏中处置的影响。
Eur J Drug Metab Pharmacokinet. 2017 Jun;42(3):519-526. doi: 10.1007/s13318-016-0367-9.

本文引用的文献

1
Physiologically based modeling of pravastatin transporter-mediated hepatobiliary disposition and drug-drug interactions.基于生理学的普伐他汀转运体介导的肝胆处置和药物相互作用的建模。
Pharm Res. 2012 Oct;29(10):2860-73. doi: 10.1007/s11095-012-0792-7. Epub 2012 May 26.
2
Long-lasting inhibitory effects of cyclosporin A, but not tacrolimus, on OATP1B1- and OATP1B3-mediated uptake.环孢素 A 对 OATP1B1 和 OATP1B3 介导摄取具有持久的抑制作用,而他克莫司则没有。
Drug Metab Pharmacokinet. 2012;27(4):368-78. doi: 10.2133/dmpk.dmpk-11-rg-096. Epub 2012 Jan 13.
3
Absolute quantification and differential expression of drug transporters, cytochrome P450 enzymes, and UDP-glucuronosyltransferases in cultured primary human hepatocytes.
在培养的原代人肝细胞中,药物转运体、细胞色素 P450 酶和 UDP-葡糖醛酸基转移酶的绝对定量和差异表达。
Drug Metab Dispos. 2012 Jan;40(1):93-103. doi: 10.1124/dmd.111.042275. Epub 2011 Oct 6.
4
Cyclosporine A, but not tacrolimus, shows relevant inhibition of organic anion-transporting protein 1B1-mediated transport of atorvastatin.环孢素 A,但不是他克莫司,显示出对阿托伐他汀经有机阴离子转运蛋白 1B1 介导的转运的相关抑制作用。
Drug Metab Dispos. 2010 Sep;38(9):1499-504. doi: 10.1124/dmd.110.032268. Epub 2010 Jun 2.
5
Regulation of human hepatic drug transporter expression by pro-inflammatory cytokines.促炎细胞因子对人肝药物转运体表达的调控。
Expert Opin Drug Metab Toxicol. 2009 Dec;5(12):1469-81. doi: 10.1517/17425250903304056.
6
Quantitative expression profile of hepatobiliary transporters in sandwich cultured rat and human hepatocytes.三明治培养的大鼠和人肝细胞中肝胆转运体的定量表达谱
Mol Pharm. 2009 Jul-Aug;6(4):1180-9. doi: 10.1021/mp900044x.
7
Regulation of drug transporter expression in human hepatocytes exposed to the proinflammatory cytokines tumor necrosis factor-alpha or interleukin-6.促炎细胞因子肿瘤坏死因子-α或白细胞介素-6作用下人类肝细胞中药物转运体表达的调控
Drug Metab Dispos. 2009 Mar;37(3):685-93. doi: 10.1124/dmd.108.023630. Epub 2008 Dec 15.
8
Absolute difference of hepatobiliary transporter multidrug resistance-associated protein (MRP2/Mrp2) in liver tissues and isolated hepatocytes from rat, dog, monkey, and human.大鼠、犬、猴和人类肝脏组织及分离的肝细胞中肝胆转运体多药耐药相关蛋白(MRP2/Mrp2)的绝对差异。
Drug Metab Dispos. 2009 Jan;37(1):66-73. doi: 10.1124/dmd.108.023234. Epub 2008 Oct 2.
9
Elevated levels of serum interleukin-6 are associated with low grade cellular rejection in patients with heart transplantation.心脏移植患者血清白细胞介素-6水平升高与低度细胞排斥反应相关。
Transplant Proc. 2006 Nov;38(9):3012-5. doi: 10.1016/j.transproceed.2006.08.113.
10
Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes.外源性物质激活原代人肝细胞中的药物传感受体对肝血窦和胆小管肝药物转运体表达的差异调节
Drug Metab Dispos. 2006 Oct;34(10):1756-63. doi: 10.1124/dmd.106.010033. Epub 2006 Jul 12.