Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Eur J Immunol. 2013 Apr;43(4):878-81. doi: 10.1002/eji.201343483.
Adenosine monophosphate-activated protein kinase (AMPK) is a serine/threonine kinase and is crucial for cellular energy homeostasis. The exact role of AMPK during memory CD8(+) T-cell differentiation, a process that changes from the metabolically active state of effector T cells to one of quiescence in memory cells is not well understood; however, a report by Cantrell and colleagues [Eur. J. Immunol. 2013. 43: 889-896] in this issue of the European Journal of Immunology shows that AMPK, by sensing glucose stress, is an important upstream molecule of mammalian target of rapamycin (mTOR) complex 1 for memory CD8(+) T-cell differentiation. This study provides new insights into how AMPK monitors energy stress to control effector and memory CD8(+) T-cell formation as discussed in this Commentary.
腺苷单磷酸活化蛋白激酶 (AMPK) 是一种丝氨酸/苏氨酸激酶，对于细胞能量稳态至关重要。然而，人们对于 AMPK 在记忆性 CD8(+) T 细胞分化过程中的具体作用还知之甚少，该过程从效应 T 细胞的代谢活跃状态转变为记忆细胞的静止状态；不过，Cantrell 及其同事在本期《欧洲免疫学杂志》上的报告[Eur. J. Immunol. 2013. 43: 889-896]表明，AMPK 通过感知葡萄糖应激，是哺乳动物雷帕霉素靶蛋白 (mTOR) 复合物 1 促进记忆性 CD8(+) T 细胞分化的一个重要上游分子。本研究为 AMPK 如何监测能量应激以控制效应器和记忆性 CD8(+) T 细胞形成提供了新的见解，正如这篇评论所讨论的那样。
