Biosynthesis of phosphatidylglycerol and phosphatidylglycerolphosphate in submitochondrial membranes isolated from guinea pig liver is absolutely dependent on CDP-diglycerides imported from microsomal membranes.
作者信息
Stuhne-Sekalec L, Stanacev N Z
机构信息
Department of Clinical Biochemistry, Banting Institute, Faculty of Medicine, University of Toronto, Ont., Canada.
出版信息
Biochem Cell Biol. 1990 Jan;68(1):111-6. doi: 10.1139/o90-015.
DOI:10.1139/o90-015
PMID:2350481
Abstract
The biosynthesis of radioactively labelled phosphatidylglycerol via phosphatidylglycerophosphate in outer and inner mitochondrial membranes isolated from guinea pig liver was found to depend absolutely on CDP-diglycerides, which could not be biosynthesized in these membranes. The requirement for CDP-diglycerides in the biosynthesis of labelled phosphatidylglycerol could be fulfilled by the transfer of biosynthesized [3H]CDP-diglycerides from the microsomal membranes to the outer and inner mitochondrial membranes.
摘要
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